Research Antibiotics, Temocillin Disodium, 100mg

Research Antibiotics, Temocillin Disodium, 100mg

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100 mg


Temocillin Disodium, 100 mg. Temocillin Disodium is the salt of Temocillin a semisynthetic, β-­lactamase resistant carboxypenicillin antimicrobial used as an alternative to carbapenems that is primarily used for Gram-negative bacteria.

Ticarcillin Disodium, USP conforms to United States Pharmacopeia specifications.

  • Category: Microbiology
  • CAS Number: 61545-06-0
  • Molecular Formula: C16H18N2Na2O7S2
  • Molecular Weight: 458.42
  • Mechanism of Action: Like other β-lactams, Temocillin Disodium interferes with penicillin binding protein (PBP) activity involved in the final phase of peptidoglycan synthesis. PBB catalyzes the pentaglycine crosslink between alanine and lysine. Without a pentaglycine crosslink, the integrity of the cell wall is compromised which leads to cell lysis and death. Temocillin is resistant to most β-lactamases, but resistance is commonly due to cells containing plasmid-encoded β-lactamases.
  • Temocillin is active against several multi-resistant Gram-negative species including Salmonella typhimurium, E. coli, Haemophilus influenzae and others. In contrast, Gram-positive bacteria, bacteria with altered penicillin-binding proteins, and Pseudomonas aeruginosa are not susceptible to temocillin.

Microbiology Applications

Temocillin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-negative microbial isolates. Medical microbiologists use this information to recommend antibiotic treatment options. Representative MIC ranges include:

E. coli 1.00 µg/mL - 64.00 µg/mL
H. influenzae β-lactamase negative: 0.25 - 0.50 µg/ml
H. influenzae β-lactamase positive: 0.50 - 1.00 µg/ml
S. aureus >128.00 µg/ml


  • Form: powder
  • Appearance: white or almost white powder
  • Source: semi-synthetic


Pitout JD, Sanders CC, Sanders WE (1997) Antimicrobial resistance with focus on beta-lactam resistance in Gram-negative bacilli. Am. J. Med. 103:51 PMID 9236486

Jules, K and Neu HC (1982) Antibacterial Activity and Beta-lactamase Stability of Temocillin. Antimicrob. Agents and Chemother. 22(3): 453-460

Rodriguez-Villalobos H et al (2006) In vitro activity of temocillin against extended spectrum beta-lactamase-producing Escherichia coli. J Antimicrob. Chemother. 57(4):771-774 PMID 16501056

Van Landuyt HW, Pyckavet MP, Lambert A and Boelaert J (1982) In vitro activity of temocillin (BRL 17421), a novel B-lactam antibiotic. Antimicrob. Agents. Chemother. 22(4):535-540 PMID 7181470

Available Documents

Made by an ISO 9001:2015 certified antibiotic manufacturer focused on creating antibiotics through fermentation.

By removing contamination and streamlining gene selection, these research antibiotics help scientists make discoveries in cell/plant biology, microbiology, virology, stem cell therapy, and cancer research. Specializing in the pharmaceutical and biotech research sectors.

These products are specifically designed for research use and are not approved for human or animal consumption. Not FDA approved.

Note: These chemicals are for research & laboratory use only. Your order will not be processed if you do not ship to a registered laboratory or research facility.

Please note: This product is not returnable.

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