Research Antibiotics, Tenofovir Alafenamide, 100 mg

Tenofovir Alafenamide, 100 mg. Tenofovir Alafenamide is an antiretroviral developed by Gilead and the anti-HIV activity was reported in 1993. It is an investigational precursor to Tenovor, a nucleotide reverse transcriptase inhibitor. Tenofovir Alafenamide is more efficient at delivering Tenofovir to target cells.

• CAS Number: 379270-37-8
• Molecular Formula: C₂₁H₂₉N₆O₅P
• Molecular Weight: 476.47
• Mechanism of Action: Tenofovir Alafenamide is a nucleotide analog reverse transcriptase inhibitor that terminates DNA transcription.
• Storage Conditions: -20C
• Tariff Code: 2933.59.5900
• Spectrum: antiretroviral

Eukaryotic Cell Culture Applications

Tenofovir Alafenamide is 1000- and 10-fold more active against HIV in vitro than Tenofovir or tenofovir disoproxil fumarate, respectively, and the compound is stable in biological matrices (Ray et al, 2016). It reduces HIV-1 viral replication in MT-2 cells with an EC50 value of 5 nM (Ray et al, 2016). During in vitro studies with activated or resting peripheral blood mononuclear cells, MT2 and Jerkat T-cell lines, authors found that Tenofovir Alafenamide did not inhibit mitochondrial DNA synthesis (Stray et al, 2017).

Specifications

• Form: Powder
• Appearance: White or off-white powder
• Source: Synthetic

References

Balzarini J et al (1993) Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)-2,6-diaminopurine Antimicrob. Agents Chemother. 37:332-338 PMID 8452366 Lee WA (2005) Selective intracellular activation of a novel prodrug of the human immunodeficiency virus reverse transcriptase inhibitor tenofovir leads to preferential distribution and accumulation in lymphatic tissue. Antimicrob Agents Chemother. 49(5):1898-1906 PMID 15855512 Ray AS, Fordyce MW, and Hitchcock MJM (2016) Tenofovir Alafenamide: A novel prodrug of tenofovir for the treatment of human immunodeficiency virus. Antiviral Res. 125:63-70 Stray KM et al (2017) Tenofovir Alafenamide (TAF) does not deplete mitochondrial DNA in human T-cell lines at intracellular concentrations exceeding clinically relevant drug exposures. Antiviral Res. 140:116-120

Available Documents

• SDS-EU
• SDS
• Product Data Sheet

Made by an ISO 9001:2015 certified antibiotic manufacturer focused on creating antibiotics through fermentation.

By removing contamination and streamlining gene selection, these research antibiotics help scientists make discoveries in cell/plant biology, microbiology, virology, stem cell therapy, and cancer research. Specializing in the pharmaceutical and biotech research sectors.

These products are specifically designed for research use and are not approved for human or animal consumption. Not FDA approved.

Note: These chemicals are for research & laboratory use only. Your order will not be processed if you do not ship to a registered laboratory or research facility.

Please note: This product is not returnable.