Research Antibiotics, Tizoxanide, 250mg

Tizoxanide, 250 mg. Tizoxanide is a metabolite of Nitazoxanide. It is an antiparasitic agent that can inhibit anaerobic bacteria, protozoa, and a range of viruses including hepatitis B and C.

• Category: Microbiology
• CAS Number: 173903-47-4
• Molecular Formula: C₁₀H₇N₃O₄S
• Molecular Weight: 265.25
• Mechanism of Action: Tizoxanide is the active metabolite Nitazoxanide. This anthelmintic agent is able to inhibit viral replication, including hepatitis B and C viruses.
• Storage Conditions: -20°C
• Spectrum: Tizoxanide is active against anaerobic bacteria, protozoa, and a range of viruses.

Eukaryotic Cell Culture Applications

The protein binding ability of Tizoxanide in goat plasma, albumin, and alpha-1-acid-glycoprotein were investigated in vitro. The protein binding percentage (at4 ug/ml) was > 95% in plasma and albumin solution, compared to only 49% in alpha-1-acid-glycoprotein solution, likely due to its acidic property (Zaho et al, 2010). The concept of 'drug repositioning'- using known molecules for new indications, was used to screen 1600 compounds in a high-throughput screening approach using glucose-deprived multicellular tumor spheroids (MCTS) to identify compounds that target dormant cancer cells in solid tumors. Since cancer cells in low glucose environments depend on oxidative phosphorylation rather than solely on glycolysis, continuous exposure is needed, and of the five compounds with MCTS activity, Nitazoxanide is the only one that reaches high plasma concentrations. Nitazoxanide activated the AMPK pathway and down-regulated c-Myc, mTOR, and Wnt signaling, suggesting it could be a candidate for anti-cancer applications (Senkowski W et al, 2015).

Microbiology Applications

Tizoxanide is effective against parasites (Leishmania mexicana, Trypanosoma cruzi), influenza A, hepatitis B and C.

Specifications

• Form: Powder
• Appearance: White to off-white powder
• Source: Synthetic

References

Korba BE et al (2008) Nitazoxanide, tizoxanide and other thiazolides are potent inhibitors of hepatitis B virus and hepatitis C virus replication. Antiviral. Res. 77(1):56-63 Senkowski W et al (2015) Three-dimensional cell culture-based screening identifies the anthelmintic drug Nitazoxanide as a candidate for treatment of colorectal cancer. Mol Cancer Ther 14(6):1504-1516 Zhao Z et al (2010) the pharmacokinetics of nitazoxanide active metabolite (tizoxanide) in goats and its protein binding ability in vitro. J. Vet. Pharmacology. Ther. 33(2):147-153

Available Documents

• SDS-EU
• SDS
• Product Data Sheet

Made by an ISO 9001:2015 certified antibiotic manufacturer focused on creating antibiotics through fermentation.

By removing contamination and streamlining gene selection, these research antibiotics help scientists make discoveries in cell/plant biology, microbiology, virology, stem cell therapy, and cancer research. Specializing in the pharmaceutical and biotech research sectors.

These products are specifically designed for research use and are not approved for human or animal consumption. Not FDA approved.

Note: These chemicals are for research & laboratory use only. Your order will not be processed if you do not ship to a registered laboratory or research facility.

Please note: This product is not returnable.