Research Antibiotics, Ticarcillin Disodium, USP, 1 gram

Ticarcillin Disodium, USP, 1 gram. Ticarcillin disodium, USP is an extended-spectrum (4th generation) β-lactam in the carboxypenicillin family. Ticarcillin Disodium (BRL 2288) was originally synthesized by Beecham Research Laboratories in 1967 and was made available for research, prior to 1970. Ticarcillin has bactericidal activity against many gram-positive and gram-negative bacteria, particularly Pseudomonas aeruginosa.

Ticarcillin Disodium is a cell wall synthesis inhibitor. It exerts bactericidal activity via inhibition of bacterial cell wall biosynthesis at the level of peptidoglycan cross-linking by inhibiting peptidoglycan transpeptidases.

In molecular biology, ticarcillin is used to as an alternative to ampicillin Sodium (A042) to test the uptake of marker genes into bacteria. It prevents the appearance of satellite colonies that occur when ampicillin breaks down in the media. It is also used in plant molecular biology to kill agrobacterium, which is used to deliver genes to plant cells.

We offer two forms of ticarcillin disodium: ticarcillin disodium (TOK-T027) and ticarcillin disodium w/clavulanate potassium (TOK-T020) (Timentin). Both forms are freely soluble in aqueous solution. Clavulanate potassium (clavulanic acid) is a β-lactamase inhibitor which can irreversibly inactivate β-lactamase enzymes of β-lactam resistant microbes preventing them from breaking down β-lactam antibiotics. Ticarcillin disodium can be combined with clavulanate potassium for greater efficacy against β-lactam resistant strains.

Ticarcillin Disodium, USP conforms to United States Pharmacopeia specifications.

• Category: Microbiology
• CAS Number: 4697-14-7
• Molecular Formula: C₁₅H₁₄N₂Na₂O₆S₂
• Molecular Weight: 428.39 g/mol
• Mechanism of Action: β-lactams, like Ticarcillin Disodium, USP, interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP"s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases.
• Storage Conditions: 2-8°C
• Tariff Code: 2941.10.5000
• Spectrum: Ticarcillin has bactericidal activity against many gram-positive and gram-negative bacteria, particularly Pseudomonas aeruginosa.

Ticarcillin can be used as a selective agent in several types of isolation media.

Plant Biology Applications

Timentin (ticarcillin Disodium/clavulanic acid) has been used in agrobacterium-mediated genetic transformation studies. Timentin shows no deleterious effect on callus proliferation and regeneration in transgenic indica rise IR64 plants in comparison to cefotaxime and carbenicillin.

Specifications

• Form: powder
• Appearance: white to pale yellow powder
• Source: Semi-synthetic
• Impurity Profile:
  • Impurity A: (2S,5R,6R)-3,3-dimethyl-7-oxo-6-[[(thiophen-3-yl)acetyl]amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid (decarboxyticarcillin)||C14H15N2O4S2|339.41
  • Impurity B: (thiophen-3-yl)acetic acid|6964-21-2|C6H6O2S|142.18
  • Impurity C: 2-(thiophen-3-yl)propanedioic acid (3-thienylmalonic acid|21080-92-2|C7H6O4S|186.19
  • Impurity D: (4S)-2-[carboxy[[2-carboxy-2-(thiophen-3-yl)acetyl]amino]methyl]-5,5-dimethylthiazolidine-4-carboxylic acid (penicilloic acids of ticarcillin)||C15H17N2O7S2|401.44
  • Impurity E: (4S)-2-[[[2-carboxy-2-(thiophen-3-yl)acetyl]amino]methyl]-5,5-dimethylthiazolidine-4-carboxylic acid (penilloic acids of ticarcillin)||C14H17N2O5S2|357.43
• Water Content (Karl Fischer): <6.0%
• pH: 6.0-8.0
• Melting Point: 252.6°C
• Optical Rotation: +172° to +187°
• Assay: Not less than 800 µg/mg (on dried basis)

References

Guzmán, Flavio, MD. "Beta Lactams Antibiotics (penicillins and Cephalosporins) Mechanism of Action." Medical Pharmacology. Pharmacology Corner, 29 Nov. 2008. Web. 21 Aug. 2012.

Pitout JD, Sanders CC, Sanders WE Jr. Antimicrobial resistance with focus on beta-lactam resistance in gram-negative bacilli. Am J Med 1997; 103:51.

Available Documents

• SDS
• Product Data Sheet
• Susceptibility and Resistance Data

Made by an ISO 9001:2015 certified antibiotic manufacturer focused on creating antibiotics through fermentation.

By removing contamination and streamlining gene selection, these research antibiotics help scientists make discoveries in cell/plant biology, microbiology, virology, stem cell therapy, and cancer research. Specializing in the pharmaceutical and biotech research sectors.

These products are specifically designed for research use and are not approved for human or animal consumption. Not FDA approved.

Note: These chemicals are for research & laboratory use only. Your order will not be processed if you do not ship to a registered laboratory or research facility.

Please note: This product is not returnable.