Research Antibiotics, Toltrazuril, 100mg

Toltrazuril, 100 mg. Toltrazuril is an antiprotozoal agent that acts upon Coccidia parasites in animals, fish, and man. Its primary metabolites include toltrazuril sulfoxide and toltrazuril sulfone. Toltrazuril can also be used as an analytical standard in food and environmental testing. The compound is soluble in DMSO.

• Category: Microbiology
• CAS Number: 69004-03-1
• Molecular Formula: C₁₈H₁₄F₃N₃O₄S
• Molecular Weight: 425.38
• Mechanism of Action: Toltrazuril induces changes in the coccidia such that the intracellular stages (schizonts, gamonts) were destroyed. Anatomical changes include swelling of the endoplasmic reticulum and Golgi, and abnormalities in nuclear division leading to a reduction in respiratory enzymes.
• Storage Conditions: 2-8°C
• Spectrum: Antiprotozoal agent

Applications

Toltrazuril can be used as an analytical standard in food and environmental testing.

Eukaryotic Cell Culture Applications

Toltrazuril was investigated in Neospora caninum using a molecular assay to distinguish between live and dead parasites. Infected cells were treated with 30 ug/ml toltrazuril for 2-20 days. NcGRA2-RT-real time PCR showed that a 10-day treatment was sufficient. This assay could be widely used to study the affect of novel compounds in the bovine host (Strohbusch et al, 2008). Cryptosporidium parvum is a protozoan parasite that is highly infectious in humans and animals, infecting the epithelial cells of the small intestine. Toltrazuril was used in vitro against oocysts to test for anticryptosporidial activity, and effectiveness was dose-dependent, with optimal being 100 ug/ml. A synergistic mixture of Toltrazuril with Monensin had the greatest efficacy (Fathi et al, 2011).

Specifications

Source: synthetic

References

Fathi M, Sadraei J, and Ghaffarifar F (2011) Effects of two anticoccidial drugs, Monensin, Toltrazuril and the mixture of them on Cryptosporidium parvum in vitro. Jundishapur J. Microbiol. 4(2): 71-74 Martinez-Villalba A, Moyano E, Martins CPB and Galceran MT (2010) Fast liquid chromatography/tandem mass spectrometry (highly selective selected reaction monitoring) for the determination of toltrazuril and its metabolites in food. Anal. Bioanal. Chem. 397(7):2893-2901 Mehlhorn H, Schmahl G and HAberkorn A (1988) Toltrazuril effective against a broad spectrum of protozoan parasites. Parasitol. Res. 75(1):64-66 PMID 3144713 Strohbusch M, Muller N, Hemphill A, Greif G and Gottstein B (2008) NcGA2 as a molecular target to assess the parasiticidal activity of toltrazuril against Neospora caninum. Parasitol. 135(9):1065-1073

Available Documents

• SDS-EU
• SDS
• Product Data Sheet

Made by an ISO 9001:2015 certified antibiotic manufacturer focused on creating antibiotics through fermentation.

By removing contamination and streamlining gene selection, these research antibiotics help scientists make discoveries in cell/plant biology, microbiology, virology, stem cell therapy, and cancer research. Specializing in the pharmaceutical and biotech research sectors.

These products are specifically designed for research use and are not approved for human or animal consumption. Not FDA approved.

Note: These chemicals are for research & laboratory use only. Your order will not be processed if you do not ship to a registered laboratory or research facility.

Please note: This product is not returnable.