Research Antibiotics, Sugammadex Sodium, 250mg

Sugammadex Sodium, 250 mg.. Sugammadex Sodium is the octasodium salt of Sugammadex. It is a synthetic derivative of gamma-cyclodextrin, discovered by Organon (Scotland). The compound acts as a reversal agent for neuromuscular blocking agents.

• Category: Microbiology
• CAS Number: 343306-79-6
• Molecular Formula: C₇₂H₁₀₄O₄₈S₈ • 8Na
• Molecular Weight: 2178.01
• Mechanism of Action: Sugammadex Sodium acts as a reversal agent for neuromuscular blocking agents (rocuronium and vecuronium). It forms a complex with the blocking agent, and reduces the amount of blocking agent available to bind to nicotinic cholinergic receptors in the neuromuscular junction. This compound is biologically inactive and does not bind to plasma proteins, and has no effect on human receptors.
• Storage Conditions: -20°C

Eukaryotic Cell Culture Applications

Sugammadex tested negatively during in vitro bacterial reverse mutation assays (Ames test),and in vitro chromosomal aberration assays in human peripheral blood lymphocytes. Sugammadex treatment on delayed-rectifier K+ ion current was investigated in differentiated NSC-34 mouse motor neuron cell line, a model for investigating neuronal development and differentiation in vitro. It was found that it influence the amplitude and gating of the current, and its actions could contribute to functional activities of motor neurons. (Hsu et al, 2017).

Specifications

• Form: powder
• Appearance: White or off-white powder
• Source: Synthetic

References

de Boer HD, van Egmond J, van de Pol F, Bom A, Booij LH (2006) Sugammadex, a new reversal agent for neuromuscular block induced by rocuronium in the anaesthetized Rhesus monkey. Br. J. Anaesth.96(4):473-479 PMID 16464982 Hsu H, Lo Y, Huang Y, Tseng Ya nd Wu S (2017) Important modifications by Sugammadex, a modified y-cyclodextrin, of ion currents in differentiated NSC-34 neuronal cells. BMC Neurosci. 18:6 Naguib M (2007) Sugammadex: Another milestone in clinical neuromuscular pharmacology. Anesth. Analg. 104(3):575-581 PMID 17312211

Available Documents

• SDS-EU
• SDS
• Product Data Sheet

Made by an ISO 9001:2015 certified antibiotic manufacturer focused on creating antibiotics through fermentation.

By removing contamination and streamlining gene selection, these research antibiotics help scientists make discoveries in cell/plant biology, microbiology, virology, stem cell therapy, and cancer research. Specializing in the pharmaceutical and biotech research sectors.

These products are specifically designed for research use and are not approved for human or animal consumption. Not FDA approved.

Note: These chemicals are for research & laboratory use only. Your order will not be processed if you do not ship to a registered laboratory or research facility.

Please note: This product is not returnable.