Research Antibiotics, Tiamulin Fumarate, 500mg

Tiamulin Fumarate, 500 mg. Tiamulin fumarate is a pleuromutilin antibiotic and is soluble in aqueous solution.

• Category: Microbiology
• CAS Number: 55297-96-6
• Molecular Formula: C₃₂H₅₁NO₈S
• Molecular Weight: 609.81
• Mechanism of Action: Pleuromutilin antibiotics inhibit protein synthesis by targeting the 50S bacterial ribosomal subunit and binding to peptidyl transferase, the enzyme responsible for forming peptide bonds between amino acids.
• Storage Conditions: 2-8°C
• Tariff Code: 2941.90.5000
• Spectrum: Tiamulin targets primarily gram positive bacteria as well as a few Mycoplasma species.

Microbiology Applications

Tiamulin fumarate is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and Mycoplasma microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

Mycoplasma hyorhinis 0.024 µg/mL – 0.097 µg/mL
Mycoplasma synoviae 0.006 µg/mL - 1 µg/mL

Specifications

• Form: powder
• Appearance: White or off-white crystalline powder
• Source: synthetic
• Impurity Profile
  Related Substances:
  • Impurity A| (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-Ethenyl-5,8-dihydroxy-4,6,9,10-tetramethyl-octahydro-3a,9-propano-3aH-cyclopentacyclo-octen-1(4H)-one (Mutilin)|6040-37-5|C20H32O3|320.5| Impurity B| 2-(Benzylsulphanyl)-N,N-diethylethanamine Hydrochloride||C13H21NS|223.38|... (inquire for complete list)
• pH 3.1-4.1
• Melting Point 143-149°C
• Optical Rotation +24.0 to +28.0°C
• Assay (On Dried Basis): 98.0-102.0%
• Loss on Drying: ≤0.5%

References

Bosling, Jacob, and et al. "Resistance to the Peptidyl Transferase Inhibitor Tiamulin Caused by Mutation of Ribosomal Protein L3." Antimicrobial Agents and Chemotherapy 47.9 (2003): 2892-896. www.ncbi.gov. Web. 10 Sept. 2012.

Available Documents

• SDS
• Product Data Sheet
• Susceptibility and Resistance Data

Made by an ISO 9001:2015 certified antibiotic manufacturer focused on creating antibiotics through fermentation.

By removing contamination and streamlining gene selection, these research antibiotics help scientists make discoveries in cell/plant biology, microbiology, virology, stem cell therapy, and cancer research. Specializing in the pharmaceutical and biotech research sectors.

These products are specifically designed for research use and are not approved for human or animal consumption. Not FDA approved.

Note: These chemicals are for research & laboratory use only. Your order will not be processed if you do not ship to a registered laboratory or research facility.

Please note: This product is not returnable.