Research Antibiotics, Tolvaptan, 10mg

Tolvaptan, 10 mg. Tolvaptan is a non-peptide aquaretic agent that functions as a selective, competitive vasopressin receptor 2 (v2) antagonist. Aquaretic agents are being studied for water-retaining disorders like congestive heart failure and live cirrhosis.

Tolvaptan has been shown to inhibit the development of polycystic kidney disease in several animal models.

• Category: BioActive Small Molecules
• CAS Number: 150683-30-0
• Molecular Formula: C₂₆H₂₅ClN₂O₃
• Molecular Weight: 448.94
• Mechanism of Action: Tolvaptan is a selective, competitive vasopressin receptor 2 (v2) antagonist, 29 times for selective than the vasopressin receptor V1a. It is a derivative of OPC-31260.
• Storage Conditions: 2-8°C
• Tariff Code: 2933.99.7900

Applications

Tolvaptan has been used as a V2-selective antagonist in mouse models of hypertension.

Eukaryotic Cell Culture Applications

Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited renal disorder. Aberrant epithelial cell proliferation is responsible for growth of cysts, which leads to nephron loss, enlarged kidneys, and decline in kidney function. Tolvaptan inhibits renal effects of arginine vasopressin (AVP) and slows cyst growth in animal models. When studying the effect of Tolvaptan using human epithelial cells from an cyst cultured in a 3D matrix, Tolvaptan was found to inhibit AVP-induced Cl− secretion and decreased in vitro cyst growth. (Reif et al, 2011).

Specifications

• Form: Powder
• Appearance: Powder
• Source: synthetic

References

Jalal GK, Hamad B, Yasothan U and Kirkpatrick P (2009) Tolvaptan. Nat. Rev. Drug Disc. 8:611-612 Reif GA et al (2011) Tolvaptan inhibits ERK-dependent cell proliferation, Cl- secretion, and in vitro cyst growth of human ADPKD cells stimulated by vasopressin. Am J Physiol Renal Physiol. 301(5):F1005-13 Schrier RW et al (2006) Tolvaptan, a selective oral vasopressin V2 receptor antagonist, for hyponatremia. N. Eng. J. Med. 355:2099-2112

Available Documents

• SDS-EU
• SDS
• Product Data Sheet

Made by an ISO 9001:2015 certified antibiotic manufacturer focused on creating antibiotics through fermentation.

By removing contamination and streamlining gene selection, these research antibiotics help scientists make discoveries in cell/plant biology, microbiology, virology, stem cell therapy, and cancer research. Specializing in the pharmaceutical and biotech research sectors.

These products are specifically designed for research use and are not approved for human or animal consumption. Not FDA approved.

Note: These chemicals are for research & laboratory use only. Your order will not be processed if you do not ship to a registered laboratory or research facility.

Please note: This product is not returnable.