Research Antibiotics, Validamycin, 1 gram

Validamycin, 1 gram. Validamycin is an antibiotic and fungicidal compound produced by Streptomyces hygroscopicus. Validamycin was first discovered in the broth of Streptomyces hygroscopicus var. limoneus T-7545, which was isolated from a soil sample collected in Akashi City, Hyogo Prefecture, Japan in 1970 (Iwasa et al., 1970), and also discovered 5 years later in the broth of S. hygroscopicus var. jinggangensis Yen. TH82, from a soil sample of Jinggang Mountain in Jiangxi, China.

Validamycin is structurally similar to trehalose and acts as a competitive inhibitor for the enzyme trehalase, which is widely spread among animals, plants, insects, and microorganisms. Trehalase enzymes are responsible for trehalose degradation and serves an important role in regulation of such mechanisms as the active transport of glucose into the intestines, reserve supply of energy, gemination of spores, etc. Validamycin is used to study trehalose biosynthesis and trehalase activity.

Validamycin is soluble in water, methanol, DMSO, DMF, acetone, and ethanol.

• Category: Plant Biology
• CAS Number: 37248-47-8
• Molecular Formula: C₂₀H₃₅NO₁₃
• Molecular Weight: 497.50
• Mechanism of Action: Validamycin is structurally similar to trehalose and acts as a competitive inhibitor for trehalase, which is the enzyme responsible for trehalose degradation and serves an important role in regulation of such mechanisms as the active transport of glucose into the intestines, reserve supply of energy, gemination of spores, etc.
• Storage Conditions: -20°C
• Tariff Code: 2941.90.1010

Eukaryotic Cell Culture Applications

Validamycin is used in studies related to trehalase activity, and trehalose biosynthesis.

Insect Biology Applications

Validamycin inhibits the key enzyme trehalase (TRE) in insects, this enzyme is responsible for trehalose degradation and has important functions in insect growth and chitin synthesis. Validamycin has the potential for pest control uses.

Plant Biology Applications

Validamycin is effective against Pellicularia sasakii and Rhizoctonia solani in plants, but only decreases their virulence instead of exhibiting a fungicidal effect. Validamycin can be used to control sheath-blight disease in rice and is most effective against soil-borne pathogens. Validamycin was effective to control tomato bacterial wilt caused by P. solanacearum (Ishikawa et al., 1996)

Specifications

• Form: Powder
• Color: White to pale yellow powder
• Source: Streptomyces hygroscopicus
• pH: 3.0-5.0
• Melting Point: 130-135°C

References

Copping LG [ed.], 2004. The Manual of Biocontrol Agents. Alton, UK: BCPC.

Available Documents

• SDS
• Product Data Sheet

Made by an ISO 9001:2015 certified antibiotic manufacturer focused on creating antibiotics through fermentation.

By removing contamination and streamlining gene selection, these research antibiotics help scientists make discoveries in cell/plant biology, microbiology, virology, stem cell therapy, and cancer research. Specializing in the pharmaceutical and biotech research sectors.

These products are specifically designed for research use and are not approved for human or animal consumption. Not FDA approved.

Note: These chemicals are for research & laboratory use only. Your order will not be processed if you do not ship to a registered laboratory or research facility.

Please note: This product is not returnable.